Narcotic bowel syndrome almost killed Matthew Perry

The sudden demise of the beloved Friends TV show actor Matthew Perry who played Chandler Bing has stunned the whole world. But only a few people know about the actor’s brush with death a few years back. In his memoir “Friends, Lovers and the Big Terrible Thing,” Perry revealed that he had a gastrointestinal perforation and had spent weeks battling for his life after his colon burst due to drug misuse, as reported by People. He was in a coma for two weeks, spent five months in the hospital, and had to use a colostomy bag for nine months. Most of us might not know that his life-threatening condition was related to a lesser-known medical condition called Narcotic Bowel Syndrome (NBS).

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Narcotic Bowel Syndrome, or NBS, is a condition that's often a hidden consequence of long-term opioid use, as mentioned in the US National Library of Medicine. Opioids, which are commonly prescribed for pain management, have become a crucial part of modern healthcare. Still, their overuse can lead to a range of adverse effects, including NBS. What sets NBS apart is that it's characterised by frequent or long-standing abdominal pain associated with extended opioid use. This pain can worsen with higher doses of opioids or prolonged use. The exact reason why NBS develops is not entirely understood, but it's thought to be related to hyperalgesia, which occurs in about 6% of chronic opioid users. This syndrome can significantly impact the patient's quality of life, often leading to multiple emergency room visits and hospital admissions.

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Recognising NBS can be tricky because it shares symptoms with various gastrointestinal disorders. The hallmark of NBS is abdominal pain that paradoxically worsens with opioid use. It can be accompanied by symptoms like nausea, vomiting, abdominal cramps, bloating, and constipation, which are typical side effects of opioids.

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Diagnosing NBS can be challenging, as there are no specific lab tests or imaging procedures to confirm it. It largely relies on a clinical assessment, the patient's medical history, and the association between long-term opioid use and worsening abdominal pain. Specific criteria can help make a diagnosis, such as progressive pain despite higher opioid doses, burning abdominal pain, and pain occurring within a specific time frame after opioid use begins.

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The primary approach to managing NBS is reducing or discontinuing opioid use. This involves a gradual tapering of opioids to minimise withdrawal symptoms and pain. Patients may also receive support through antidepressants, clonidine, and benzodiazepines to alleviate withdrawal symptoms. Moreover, many individuals with NBS may require laxatives and peripheral opioid antagonists to manage constipation. Additionally, psychosocial therapy plays a vital role in preventing relapse.

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Preventing NBS primarily involves responsible opioid use. Healthcare providers need to be aware of the potential for NBS and strive to create a strong patient-doctor relationship built on trust and empathy. This can help patients avoid escalating opioid use to manage their pain. Encouraging alternative pain management strategies and addressing unrealistic patient expectations are crucial steps in prevention.
Constipation is a common side effect of opioids, so it's essential to start a laxative regimen simultaneously when prescribing opioids to prevent constipation. Lifestyle changes, such as staying hydrated, exercising, and adding fibre to the diet, can also help manage constipation. Furthermore, using newer peripheral opioid antagonists like alvimopan or methylnaltrexone can be considered for severe constipation.

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